1. It is possible that Spider-Man may have been given a new weakness or vulnerability in recent comic book storylines.
2 Some fans have speculated that the statement may refer to the character Kindred, who has been revealed to be a corrupted version of Harry Osborn, one of Spider-Man's closest friends.
3. Kindred's powers and abilities have not been fully revealed, but it is suggested that he has a connection to the supernatural, which may give him an edge over Spider-Man.
4. Another possible candidate for Spider-Man's "Kryptonite" is the villain Sin-Eater, who has recently resurfaced in the comics.
5. In the comics, Sin-Eater possesses a special gun that can purify souls, which could potentially be used against Spider-Man.
6. The statement could also refer to the new Spider-Man video game, Marvel's Spider-Man
7. Spider-Man's spider-sense is one of his most important abilities, allowing him to detect danger before it happens.
8. The Tinkerer's ability to disrupt this power could make it more difficult for Spider-Man to fight her.
9. However, it should be noted that the Tinkerer is not a completely new villain, having been introduced in the comics back in the 1960s.
10. Ultimately, it is unclear exactly what the statement means, and until more information is released by Marvel, it is simply speculation.